Product overview

What to know about Zypan®

Zypan is a practitioner-dispensed digestive formula introduced in 1958. Betaine hydrochloride and pepsin support the gastric environment used for protein digestion, while pancreatin supplies additional enzyme activity. Its enteric-coated design helps deliver enzymes farther into the digestive tract.*

Key label facts

Per two tablets: a 595 mg proprietary blend including betaine hydrochloride, pepsin and pancreatin. Blend weight does not measure enzyme activity. The manufacturer advises against chewing the tablets.

These are labeled serving facts. Follow this product’s manufacturer directions and full cautions.

  • Supports healthy protein digestion with pepsin and betaine hydrochloride.*
  • Helps maintain the gastric pH environment needed for normal enzyme function.*
  • Provides pancreatin for additional digestive enzyme support.*
  • Uses an enteric coating to support delivery within the digestive tract.*

Ingredients and dietary attributes

Ingredient overview

The proprietary blend contains betaine hydrochloride, bovine pancreas Cytosol™ extract, pepsin, pancreatin, ammonium chloride, bovine spleen and ovine spleen, with cellulose and calcium stearate.

Dietary and allergen considerations

  • Gluten Free
  • Non-Dairy Formula
  • Non-Soy Formula
  • Non-Grain Formula
  • Not vegetarian

Contains animal-derived ingredients and is not vegetarian. Products containing hydrochloric acid may not be appropriate for everyone. Consult your healthcare practitioner, particularly if you have digestive symptoms or use acid-reducing medication.

Use the ingredient statement and label on the package you receive as the current source for dietary decisions.

Nutrient references

Ingredient research context

These NIH resources explain ingredients in the formula. They do not test or endorse this product.

Review current Zypan® label and listing in the WSNC inSITE store ↗ for the ingredients and nutrients in this product. The references below give ingredient or nutrient context; they do not test or endorse the formula.

  • Calcium

    This NIH resource provides background on calcium. Check the current product label for the ingredient form and amount; this reference does not test or endorse Zypan®. NIH background: Calcium ↗

Compare the label details

Acid and enzyme formula comparisons

Labeled serving amounts, formula roles and dietary considerations. These are label comparisons, not rankings of effectiveness. Review the complete cautions and discuss individual suitability with a licensed practitioner.

Compare recorded product information, then open each full product page for complete ingredients and cautions. Serving instructions are product-specific.
ProductListing focusDeclared formula in briefLabel directions
Zypan®View product →Standard ProcessDigestive support combining betaine hydrochloride, pepsin and pancreatin to support normal gastric pH and healthy protein digestion.*The proprietary blend contains betaine hydrochloride, bovine pancreas Cytosol™ extract, pepsin, pancreatin, ammonium chloride, bovine spleen and ovine spleen, with cellulose and calcium stearate.Two tablets with each meal, or as directed. Swallow the tablets whole; chewing is not recommended.Full ingredients and cautions →
Multizyme®View product →Standard ProcessA broad digestive-enzyme formula with pancreatin plus plant and microbial enzymes for the breakdown of proteins, carbohydrates and fats.*Standard Process listing text identifies a 360 mg proprietary blend per capsule containing date powder, defatted almond, pancreatin (3x), bromelain, organic pineapple fruit powder, papain, amylase, lipase and cellulase. Its linked Supplement Facts image identifies a 464 mg blend per capsule with pancreatin listed first. These official materials differ; confirm the version on your package with your healthcare practitioner. The capsule ingredients include gelatin.One capsule per meal, or as directed by your healthcare practitioner.Full ingredients and cautions →
EnzycoreView product →Standard ProcessA vegetarian microbial-enzyme and L-glutamine blend supporting digestion of fats, proteins and carbohydrates throughout the digestive tract.*One capsule lists a 555 mg proprietary blend of L-glutamine, kale, beet and twelve named enzyme activities, including lactase, alpha-galactosidase and lipase. The label does not separately quantify L-glutamine or enzyme activity units. Cellulose capsule.One capsule three times daily with meals, or as directed by your healthcare practitioner.Full ingredients and cautions →

How we distinguish product facts from ingredient research →

Common questions

Zypan® FAQ

Clear answers based on the current manufacturer listing and practitioner context.

What does Zypan support?

Zypan is formulated to support normal gastric acidity, enzyme function and healthy protein digestion. It is not intended to diagnose or treat digestive disease.*

Does Zypan contain hydrochloric acid?

Yes. Zypan contains betaine hydrochloride along with pepsin and pancreatin.

Can Zypan tablets be chewed?

No. The manufacturer specifically advises against chewing because the tablets use an enteric coating.

Is Zypan vegetarian?

No. It contains bovine and ovine tissue ingredients and animal-derived digestive components.

What sizes are available?

The WSNC inSITE store lists 90 tablets, part 8430, and 330 tablets, part 8480.

What should I compare on the Zypan® label?

Per two tablets: a 595 mg proprietary blend including betaine hydrochloride, pepsin and pancreatin. Blend weight does not measure enzyme activity. The manufacturer advises against chewing the tablets. Follow each product’s manufacturer directions and full cautions; related formulas are not interchangeable doses.

Source transparency

Product sources and review notes

Product details and formulas may change. Review the current manufacturer listing and the label on the package before use. The date above records a price check; it is not an editorial review date. How we research product information →

Captioned label explainers

Watch the formula and package distinctions

Zypan and Multizyme: read the differences

A captioned comparison of Zypan and Multizyme ingredient approaches, serving directions, almond and animal ingredients, and label cautions.

Watch with the complete transcript →